When a mysterious epidemic of blindness sweeps over a city and panics its citizens, the US Minister of Health (Sandra Oh) responds by placing the afflicted into strict quarantine. Meant to keep the newly blind safe until a cure is developed and order is restored, the plan proves to have unexpected consequences when a renegade patient (Gael García Bernal) proclaims himself ruler of the hospital and his followers take control of the facilities. Amongst the chaos, a woman (Julianne Moore) who followed her afflicted husband (Mark Ruffalo) into quarantine and has kept her health a secret, bands together with a group of strangers to find their way to freedom. Directed by Fernando Meirelles. With Alice Braga and Danny Glover. Categories: Drama, Mystery, Thriller. Year: 2008.

Mark Ruffalo in Blindness
After years of ripping off millionaires using elaborate, literary-inspired schemes, Stephen (Mark Ruffalo) and Bloom (Adrien Brody), the world's greatest conmen, decide to take on one final job. Teaming up with a silent weapons expert (Rinko Kikuchi), the Brothers Bloom set their sights on Penelope Stamp (Rachel Weisz), an eccentric heiress who collects hobbies like other people collect stamps. Their plan to swindle Penelope out of $2.5 million during a romantic, around the world adventure is complicated when she and Bloom fall in love. Directed by Rian Johnson. With Robbie Coltrane and Nora Zehetner. Categories: Adventure, Comedy, Crime, Drama, Romance. Year: 2008.

Mark Ruffalo in The Brothers Bloom
Using archival footage, animation, and music, this politically-charged documentary examines the eight anti-war protesters put on trial following the 1968 Democratic National Convention. Directed by Brett Morgen. With the voices of Hank Azaria, Dylan Baker, Nick Nolte, Mark Ruffalo, Liev Schreiber and Jeffrey Wright. Categories: Documentary, Animation. Year: 2007.

Mark Ruffalo in Chicago 10
On their way home from his son's recital, college professor Ethan Learner (Joaquin Phoenix), his wife Grace (Jennifer Connelly), and their daughter Emma (Elle Fanning) watch as the boy is killed in a hit-and-run accident. The driver Dwight Arno (Mark Ruffalo) is returning his son Lucas (Eddie Alderson) to his ex-wife (Mira Sorvino) after attending a baseball game. In one terrible instant, the two father's lives are devasted. As Ethan sets out to track down his son's killer, Dwight makes the difficult choice to cover up his horrible act and deals with the unbearable guilt that follows. Directed by Terry George. Categories: Drama, Thriller. Year: 2007.

Mark Ruffalo in Reservation Road
Newspaper cartoonist Robert Graysmith (Jake Gyllenhaal) becomes obsessed with tracking down the Zodiac, a serial killer who terrorized San Francisco with a string of murders and cryptic messages to the media during the 1960s and 1970s. Though he has no personal stake in the case, Graysmith slowly pieces together missed clues and identifies possible suspects with the help of newspaper reporter Paul Avery (Robert Downey Jr.) and Inspector David Toschi (Mark Ruffalo), even as the crimes are forgotten by the rest of the city. Directed by David Fincher. With Anthony Edwards, Brian Cox and Chloë Sevigny. Categories: Crime, Drama, Thriller, Based on a True Story. Year: 2007.

Mark Ruffalo in Zodiac
"Boss" Willie Stark (Sean Penn), an idealistic southern politician loosely based on Governor Huey Long of Louisiana, appeals to the common man to earn his place of power. But, Stark's victories have their price, eventually leading him to his downfall after being corrupted by the system. Directed by Steven Zaillian. With Jude Law, Anthony Hopkins, Kate Winslet, Mark Ruffalo and James Gandolfini. Categories: Drama. Year: 2006.

Mark Ruffalo in All the King's Men
When David (Mark Ruffalo) moves into a new apartment, he is shocked when the spirit of the former tenant, a workaholic doctor named Elizabeth (Reese Witherspoon), starts haunting the place. Is she real, or just a figment of his imagination? The trouble is, he's falling in love with her. His slacker buddy, played by Jon Heder of Napoleon Dynamite, urges him to go for it, even if she is a ghost. Directed by Mark Waters. With Ivana Milicevic, Donal Logue, Ron Canada and Dina Waters. Categories: Comedy, Fantasy, Romance. Year: 2005.

Mark Ruffalo in Just Like Heaven
After becoming engaged to her boyfriend Jeff (Mark Ruffalo), Sarah Huttington (Jennifer Aniston) travels home to Pasadena for her sister Annie's (Mena Suvari) wedding. Unsure about her new engagement and the direction of her career, Sarah's life is further complicated when she learns that her mother (Jennifer Bini Taylor) and grandmother (Shirley MacLaine) may have been the inspiration for the novel The Graduate. To learn the truth, Sarah tracks down Beau Burroughs (Kevin Costner), who she believes might be her father. But, when she learns that isn't the case, she ends up falling in love with him, adding another chapter to this timeless love story. Directed by Rob Reiner. With Richard Jenkins, Christopher McDonald, Mike Vogel and Kathy Bates. Categories: Comedy, Romance. Year: 2005.

Mark Ruffalo in Rumor Has It...
Jenna (Jennifer Garner) is a 13-year-old girl who can’t wait to grow up and enjoy all the privileges that go along with being an adult. Less than popular, she spends most of her time with her best friend and neighbor, Matt Flamhaff (Mark Ruffalo). After an embarrassing 13th birthday, Jenna wishes to be all grown up, and wakes up the next day to discover that it's 2004 and she's a beautiful, successful 30-year-old woman. With Judy Greer, Andy Serkis and Kathy Baker. Categories: Comedy, Drama, Romance, Fantasy. Year: 2004.

Mark Ruffalo in 13 Going on 30
A cab driver named Max (Jamie Foxx) has his mundane life interrupted when he is taken hostage by Vince (Tom Cruise), an engaging contract killer making his rounds from hit to hit during one night in LA. Max is too afraid to act at first, but as the seriousness of what is happening becomes apparent, he decides he must find a way to save both himself and one last victim. Directed by Michael Mann. With Jada Pinkett Smith, Mark Ruffalo, Peter Berg, Bruce McGill and Debi Mazar. Categories: Crime, Drama, Thriller. Year: 2004.

Mark Ruffalo in Collateral
When Joel (Jim Carrey) discovers that his girlfriend, Clementine (Kate Winslet), has had the memories of their turbulent relationship erased from her brain by a professional service, he decides to have Clementine removed from his mind as well. But, as Joel's memories are removed one by one, he begins to recall the happy moments he spent with Clemintine and attempts to escape the procedure. Directed by Michel Gondry. With Elijah Wood, Mark Ruffalo, Kirsten Dunst and David Cross. Categories: Drama, Romance, Sci-Fi. Year: 2004.

Mark Ruffalo in Eternal Sunshine of the Spotless Mind